Saffron and DEPRESSION

“Saffron and its constituents have been extensively investigated for its antidepressant effects”…”There are several studies investigating the antidepressant effects of crocin and ethanolic extracts of saffron in vivo”…”saffron may exert antidepressant effects comparable to those of pharmaceutical antidepressants such as fluoxetine, citalopram, and imipramine, with possibly fewer observed side effects.

Read more (and for full references) - https://www.sciencedirect.com/science/article/abs/pii/S0165032717315884

(A non systemic review from 2018).